Target Weed: Smooth & Large Crabgrass Host Turfgrass: Tall Fescue Safe Selective Matches: 5

How to Kill Smooth & Large Crabgrass in Tall Fescue Without Hurting Your Lawn

Direct Agronomic Answer

To selectively kill Smooth & Large Crabgrass in Tall Fescue without damaging your turf, apply Tenacity (Mesotrione 40%), Drive XLR8 (Quinclorac 18.92%) when air temperatures are between 55°F and 85°F.

For early 1–3 leaf stages and mature 2–4 tiller plants, Quinclorac paired with a methylated seed oil (MSO) surfactant provides rapid systemic control within 7 to 14 days. In St. Augustine and Centipede lawns where Quinclorac causes severe chlorosis, Atrazine or Mesotrione (for Centipede only) must be used instead.

1. Labeled Safe Herbicides That Kill Smooth & Large Crabgrass in Tall Fescue

Recommended Product Active Ingredient & Group Application Temp (°F) Surfactant & Mixing Protocol Where to Buy
Tenacity
EPA Reg. 100-1267
Mesotrione 40%
Group 27 (HPPD Inhibitor)
55°F – 85°F
Rainfast: 6h
Always apply with Non-Ionic Surfactant (NIS) at 1 tsp (5 mL) per gallon of water for post-emergent applications. Causes temporary white bleaching on susceptible weeds and turf tips. Check Price at DoMyOwn View on Amazon
Drive XLR8
EPA Reg. 7969-272
Quinclorac 18.92%
Group 4 (Synthetic Auxin / Quinoline Carboxylic Acid)
60°F – 85°F
Rainfast: 1h
Requires Methylated Seed Oil (MSO) surfactant at 1.5 tbsp (0.75 fl oz) per gallon of water for effective cuticle penetration on multi-tiller crabgrass. Check Price at DoMyOwn View on Amazon
Acclaim Extra
EPA Reg. 432-950
Fenoxaprop-p-ethyl 6.59%
Group 1 (ACCase Inhibitor)
60°F – 85°F
Rainfast: 1h
Add Non-Ionic Surfactant (NIS) at 0.5 tsp per gallon only when targeting mature multi-tiller Goosegrass or Japanese Stiltgrass. Never tank-mix with 2,4-D (causes antagonism). Check Price at DoMyOwn View on Amazon
Pylex Herbicide
EPA Reg. 7969-327
Topramezone 29.7%
Group 27 (HPPD Inhibitor / Pyrazolone)
55°F – 85°F
Rainfast: 1h
Must be applied with Methylated Seed Oil (MSO) at 1 to 1.5 tsp per gallon of water. Tank-mixing with Triclopyr Ester reduces white bleaching and speeds up Bermudagrass and Goosegrass mortality. Check Price at DoMyOwn View on Amazon
Barricade 4FL (Prodiamine 65 WDG)
EPA Reg. 100-1139
Prodiamine 40.7% (or 65% WDG)
Group 3 (Microtubule Assembly Inhibitor / Dinitroaniline)
45°F – 90°F
Rainfast: 0h
Pre-emergent soil barrier: do NOT use foliar surfactant. Must be watered in with 0.5 inches of irrigation or rainfall within 14 days of application to activate. Check Price at DoMyOwn View on Amazon

2. What NOT to Spray on Tall Fescue When Treating Smooth & Large Crabgrass

Warning: Common Smooth & Large Crabgrass Killers That Damage Tall Fescue

Many retail herbicides advertised for Smooth & Large Crabgrass are formulated for different turf zones and will severely injure Tall Fescue:

  • AVOID Hi-Yield Atrazine Weed Killer (Atrazine 40.8%): Rated 'avoid' on Tall Fescue — high risk of turf phytotoxicity or stunting.

3. Optimal Seasonal Timing & Temperature Thresholds

Apply pre-emergent Prodiamine or Dithiopyr when 4-inch soil temperatures reach 50°F–55°F for three consecutive days, and spray post-emergent herbicides in late spring when seedlings have 2 to 3 leaves.

Post-emergent applications are most effective when Crabgrass is actively growing in moist soil and air temperatures remain below 85°F. Spraying mature multi-tiller plants in late August during drought stress significantly reduces herbicide translocation.

4. Diagnostic Checklist: Confirm It Is Smooth & Large Crabgrass Before Spraying

Not 100% sure? Use our AI Photo Weed Scanner or review the full Smooth & Large Crabgrass Botanical Profile.